Review: Found in Translation: International Initiatives Pursuing Interleukin-1 Blockade for Treatment of Acute Kawasaki Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27792871.
- Also identified by DOI 10.1002/art.39975 and PMC identifier 5274552.
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Abstract
The decision to move forward with three clinical trials of IL-1 blockade for treatment of acute Kawasaki disease is a case study in translational science. These trials were born on the one hand from transcriptome studies of host response during the acute disease coupled with animal model investigations of key immune signaling pathways and, on the other hand, out of clinical desperation to intervene in patients with severe inflammation in the setting of acute Kawasaki disease. The convergence of laboratory science and clinical observations led to the clinical trials described here and serves as a model for how such observations can be translated into new therapies.
Medical subject headings
- Antirheumatic Agents
- Immunoglobulins, Intravenous
- Interleukin-1
- Mucocutaneous Lymph Node Syndrome