Therapeutics for Brain Metastases, v3.
basic_science · Level V
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- Record sourced from PubMed, PMID 27803066.
- Also identified by PMC identifier 6545573.
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Abstract
The role of blood-brain barrier (BBB) permeability in the efficacy of brain metastasis therapeutics is debated. Both BBB-permeable and BBB-impermeable compounds were compared in a melanoma brain metastasis model using imaging through a cranial window. Only the BBB-permeable compound inhibited both the ∼30% permeable metastases and the ∼70% impermeable metastases. Clin Cancer Res; 22(24); 5953-5. ©2016 AACRSee related article by Osswald et al., p. 6078.
Medical subject headings
- Antineoplastic Agents
- Brain Neoplasms