Role of the inter-protofilament sliding in the bending of protein microtubules.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27810106.
- Also identified by DOI 10.1016/j.jbiomech.2016.10.008.
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Abstract
This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the inter-PF sliding during the bending. When the angle spring is soft inter-PF sliding occurs leading to the length-dependent bending stiffness of MTs. Such a size dependent bending stiffness may also affect the vibration and buckling behavior of MTs where bending deformation is predominant.
Medical subject headings
- Microtubules
- Models, Molecular