Leukemic Stem Cells S(p)liced Off.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27814474.
- Also identified by DOI 10.1016/j.stem.2016.10.016.
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Abstract
Myeloid malignancies often arise from an aging hematopoietic system and are currently incurable due to therapy-resistant, disease-reinitiating leukemic stem cells. In this issue of Cell Stem Cell, Crews et al. (2016) report RNA splice isoform signatures unique to patient-derived leukemic stem cells that constitute a therapeutic Achilles' heel of myeloid leukemia.
Medical subject headings
- Leukemia, Myeloid, Acute
- Stem Cells