The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant.
editorial · Level V
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- Record sourced from PubMed, PMID 27814477.
- Also identified by DOI 10.1016/j.stem.2016.10.010.
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Abstract
The molecular features underlying tumor heterogeneity and the role of chromatin components in regulating cell fate within tumors are not well understood. Recently in Science, Torres et al. (2016) showed that the linker histone variant H1.0 functions as a chromatin switch that determines self-renewal versus differentiation decisions in cancer stem cells.
Medical subject headings
- Chromatin
- Histones