A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs.
basic_science · Level V
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- Record sourced from PubMed, PMID 27819659.
- Also identified by DOI 10.1038/nmeth.4066 and PMC identifier 5554622.
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Abstract
Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.
Medical subject headings
- Evolution, Molecular
- Phylogeny
- RNA, Long Noncoding