Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?
Where this comes from
- Record sourced from PubMed, PMID 27824890.
- Also identified by DOI 10.1371/journal.pone.0165782 and PMC identifier 5100971.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Crohn's Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1High/Th2Low while, by contrast, the group with Th1Low/Th2High will benefit from immune activation.
Medical subject headings
- Inflammatory Bowel Diseases
- Tumor Necrosis Factor-alpha