Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27829133.
- Also identified by DOI 10.1016/j.cmet.2016.10.015.
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Abstract
Both cancer cells and activated T and NK immune cells display enhanced nutrient uptake and metabolism characteristic of the Warburg phenotype. In this issue of Cell Metabolism, Brand et al. (2016) demonstrate that cancer cell LDHA-derived lactic acid selectively disables T and NK cell activation and tumor immune surveillance.
Medical subject headings
- Killer Cells, Natural
- Lactic Acid