Metabolic Signaling Drives IFN-γ.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27829134.
- Also identified by DOI 10.1016/j.cmet.2016.10.018 and PMC identifier 5292925.
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Abstract
IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.
Medical subject headings
- Epigenesis, Genetic
- Interferon-gamma