Macrophage Metabolism Shapes Angiogenesis in Tumors.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27829135.
- Also identified by DOI 10.1016/j.cmet.2016.10.016.
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Abstract
In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.
Medical subject headings
- Macrophages
- Neovascularization, Pathologic