Airway pressure and outcome of out-of-hospital cardiac arrest: A prospective observational study.

Abstract

To assess the usefulness of airway pressure as predictor of return of spontaneous circulation (ROSC), as well as to investigate the optimized ventilation compression strategy during cardiopulmonary resuscitation (CPR). In this prospective observational study, 300 out-of-hospital cardiac arrest victims were intubated and resuscitated with the use of a ventilator. Mean airway pressure (mPaw) was measured at pre-defined phases of CPR. A significant difference in mPaw was observed between survivors and non-survivors after the onset of the third minute of CPR. An mPaw value of 42.5mbar during CPR had specificity and sensitivity of 0.788 and 0.804, respectively, for ROSC (AUC=0.668, p=0.047). During CPR, we found statistically significant differences in mPaw at phases zero (F=4.526, p=0.002), two (F=4.506, p=0.002), four (F=8.187, p<0.0001), five (F=2.871, p=0.024), and six (F=5.364, p<0.0001). Mean airway pressure was higher in survivors. A value of 42.5mbar was associated with ROSC.