The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27863237.
- Also identified by DOI 10.1016/j.cell.2016.10.054 and PMC identifier 5131802.
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Abstract
Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.
Medical subject headings
- Enhancer Elements, Genetic
- Promoter Regions, Genetic