Role of Recombinant Human Bone Morphogenetic Protein-2 on Hindfoot Arthrodesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27871412.
- Also identified by DOI 10.1016/j.fcl.2016.07.001.
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Abstract
Despite advances in understanding bone healing physiology and surgical techniques, delayed union and nonunion still occur after the treatment of hindfoot arthrodesis. There is increasing appeal of bone morphogenetic proteins (BMPs) owing to the innate osteoinductive abilities of BMPs. Effective treatment with BMPs has been shown in animal studies. Human clinical studies have also shown success. The only study investigating the use of recombinant human BMP (rhBMP)-2 in hindfoot arthrodesis found a significant increase in fusion rate. Treatment cost effective. Complications from their use remain low. rhBMP-2 is a safe and effective bone-healing adjunct in hindfoot arthrodesis surgery.
Medical subject headings
- Arthrodesis
- Bone Density Conservation Agents
- Bone Morphogenetic Protein 2
- Foot
- Fracture Healing
- Fractures, Ununited
- Transforming Growth Factor beta
Anatomy
- foot