MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27884305.
- Also identified by DOI 10.1016/j.kint.2016.08.032.
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Abstract
Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.
Medical subject headings
- Exosomes
- Extracellular Vesicles
- MicroRNAs