Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27885722.
- Also identified by DOI 10.1002/adma.201604043 and PMC identifier 5250559.
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Abstract
A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow. This "smart" heparin patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate blood coagulation in response to thrombin.
Medical subject headings
- Thrombin