Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27892469.
- Also identified by DOI 10.1038/ncomms13491 and PMC identifier 5133696.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes highly racemizable 3,5-dihydroxyphenylglycines (Dpgs). Here we describe the total synthesis of feglymycin based on a linear/convergent hybrid approach. Our originally developed micro-flow amide bond formation enabled highly racemizable peptide chain elongation based on a linear approach that was previously considered impossible. Our developed approach will enable the practical preparation of biologically active oligopeptides that contain highly racemizable amino acids, which are attractive drug candidates.
Medical subject headings
- Amides
- Proteins
- Rheology