A scored human protein-protein interaction network to catalyze genomic interpretation.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27892958.
- Also identified by DOI 10.1038/nmeth.4083 and PMC identifier 5839635.
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Abstract
Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.
Medical subject headings
- Computational Biology
- Data Interpretation, Statistical
- Gene Regulatory Networks
- Genomics
- Neoplasms
- Protein Interaction Maps