Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27895033.
- Also identified by DOI 10.1158/1078-0432.CCR-16-0133 and PMC identifier 5453188.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions or reprogramming toward an antitumorigenic phenotype, with varying degrees of efficacy. Here, we review preclinical and clinical strategies to target macrophages in cancer and discuss potential explanations for why some strategies are effective while other approaches have shown limited success. <i>Clin Cancer Res; 23(4); 876-84. ©2016 AACR</i>.
Medical subject headings
- Molecular Targeted Therapy
- Neoplasms