Ghrelin function in human obesity and type 2 diabetes: a concise review.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27899023.
- Also identified by DOI 10.1111/obr.12474.
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Abstract
The 28 amino acid hormone, ghrelin, has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin's effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin-mediated lipid retention could establish new mechanisms underlying cellular energy homeostasis. The impact of acyl-ghrelin on glucose metabolism and lipid homeostasis may allow for novel preventative or early intervention therapeutic strategies to treat obesity related type 2 diabetes and associated metabolic dysfunction.
Medical subject headings
- Diabetes Mellitus, Type 2
- Ghrelin
- Obesity