Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27911956.
- Also identified by DOI 10.1371/journal.pone.0167445 and PMC identifier 5135100.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer. Together, these data suggest important roles of the A2B receptors and NaV1.5 channels in the Ado-induced increase in proliferation and migration of the MDA-MB 231 cells.
Medical subject headings
- Adenosine
- Breast Neoplasms
- Cell Movement
- Cell Proliferation
- Second Messenger Systems