Retromer Sets a Trap for Endosomal Cargo Sorting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27912055.
- Also identified by DOI 10.1016/j.cell.2016.11.026.
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Abstract
Membrane trafficking from endosomes to the trans-Golgi network or the plasma membrane is driven by the retromer complex. Through structural analysis of the cargo-bound complex, Lucas et al. describe a mechanism by which endosomal membrane recruitment and cargo recognition are integrated through cooperative interactions between retromer subunits.
Medical subject headings
- Endosomes
- trans-Golgi Network