PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance.
editorial · Level V
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- Record sourced from PubMed, PMID 27912085.
- Also identified by DOI 10.1016/j.stem.2016.11.010 and PMC identifier 5444322.
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Abstract
Adipocyte progenitor proliferation and self-renewal contribute to adipose tissue maintenance; however, the regulatory circuits of these processes are less understood. In this issue of Cell Stem Cell, Rivera-Gonzalez et al. (2016) show that PDGFA, which acts through PI3K-Akt pathways, plays a vital role in the proliferation and maintenance of adipocyte progenitors in dermal adipose tissues.
Medical subject headings
- Adipocytes
- Phosphatidylinositol 3-Kinases