An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27918115.
- Also identified by DOI 10.1002/adma.201603702.
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Abstract
An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self-assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic <sup>1</sup> O<sub>2</sub> , both of which can inhibit tumor growth.
Medical subject headings
- Ruthenium