Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo.

Cheng, Xiaju; Sun, Rui; Yin, Ling; Chai, Zhifang; Shi, Haibin; Gao, Mingyuan · Adv Mater · 2017

basic_science · Level V

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Abstract

Photocross-linkable Au nanoparticles are prepared through surface decoration of photolabile diazirine moieties. Both in vitro and in vivo studies indicate that the light-triggered cross-linking can dramatically shift the surface plasmon resonance of Au nanoparticles to near-infrared regions, which in consequence remarkably enhances their efficacy for photothermal therapy and photoacoustic imaging of tumors in vivo.

Medical subject headings