Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.
basic_science · Level V
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- Record sourced from PubMed, PMID 27930303.
- Also identified by DOI 10.1073/pnas.1611408114 and PMC identifier 5187668.
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Abstract
Dendritic cells (DCs) and monocytes develop from a series of bone-marrow-resident progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an E-box-binding protein associated with epithelial-mesenchymal transition and is widely expressed among hematopoietic lineages. Previously, we observed that Zeb2 expression is differentially regulated in progenitors committed to classical DC (cDC) subsets in vivo. Using systems for inducible gene deletion, we uncover a requirement for Zeb2 in the development of Ly-6C<sup>hi</sup> monocytes but not neutrophils, and we show a corresponding requirement for Zeb2 in expression of the M-CSF receptor in the bone marrow. In addition, we confirm a requirement for Zeb2 in development of plasmacytoid DCs but find that Zeb2 is not required for cDC2 development. Instead, Zeb2 may act to repress cDC1 progenitor specification in the context of inflammatory signals.
Medical subject headings
- Dendritic Cells
- Gene Expression Regulation
- Monocytes
- Zinc Finger E-box Binding Homeobox 2