Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27932616.
- Also identified by DOI 10.1093/infdis/jiw568 and PMC identifier 6374017.
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Abstract
Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.
Medical subject headings
- Epithelial Cells
- Fallopian Tubes
- Gonorrhea
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Neisseria gonorrhoeae