Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27936229.
- Also identified by DOI 10.1371/journal.pone.0167936 and PMC identifier 5148029.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.
Medical subject headings
- Blood Vessels
- Calcinosis
- Endothelium, Vascular
- Insulin
- Mesoderm