Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macroenvironments.

Kamperman, Tom; Henke, Sieger; van den Berg, Albert; Shin, Su Ryon; Tamayol, Ali; Khademhosseini, Ali; Karperien, Marcel; Leijten, Jeroen · Adv Healthc Mater · 2017

basic_science · Level V

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Abstract

Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro- and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution. This approach represents a major step forward in endowing engineered constructs with the multifunctionality that underlies the behavior of native tissues.

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