Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27974177.
- Also identified by DOI 10.1016/j.cmet.2016.11.012.
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Abstract
Intermediary metabolism provides substrates that shape epigenetic status, but whether this interaction can be responsible for oncogenesis is largely unknown. In a recent issue of Nature, Kottakis et al. (2016) now show that the common tumor suppressor gene LKB1 can function by mediating this connection through an LKB1/AMPK/mTOR signaling axis.
Medical subject headings
- AMP-Activated Protein Kinases
- Protein Serine-Threonine Kinases