A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27976536.
- Also identified by DOI 10.1002/adhm.201601091 and PMC identifier 5322155.
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Abstract
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.
Medical subject headings
- Catecholamines
- Coated Materials, Biocompatible
- Membranes, Artificial
- Phosphorylcholine