A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 27976721.
- Also identified by DOI 10.1038/ncomms13760 and PMC identifier 5172377.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P=1.94 × 10<sup>-8</sup>, OR=0.89), rs4720118 on 7p14.3 (P=3.85 × 10<sup>-10</sup>, OR=1.16), rs55894533 on 8p23.1 (P=5.07 × 10<sup>-11</sup>, OR=1.15) and rs10100465 on 8q24.11 (P=2.85 × 10<sup>-11</sup>, OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.
Medical subject headings
- Asian People
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 7
- Chromosomes, Human, Pair 8
- Leprosy