A Breakdown in Cooperativity Leads to Cardiac Identity Crisis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27984717.
- Also identified by DOI 10.1016/j.cell.2016.11.056.
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Abstract
Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.
Medical subject headings
- GATA4 Transcription Factor
- Identity Crisis