A Zygotic Checkpoint for Unrepaired Lesions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27984718.
- Also identified by DOI 10.1016/j.cell.2016.11.049.
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Abstract
DNA demethylation, a process involving DNA repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition. A new study by Ladstätter and Tachibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrepaired lesions from entering mitosis.
Medical subject headings
- DNA Methylation
- Zygote