Broncho Alveolar Dendritic Cells and Macrophages Are Highly Similar to Their Interstitial Counterparts.
Where this comes from
- Record sourced from PubMed, PMID 27992536.
- Also identified by DOI 10.1371/journal.pone.0167315 and PMC identifier 5167224.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In human medicine, bronchoalveolar lavage is the main non-traumatic procedure allowing an insight into the respiratory Dendritic Cells (DC) and Macrophages populations. However, it has never been demonstrated in a relevant model that alveolar DC subpopulations were comparable to their interstitial counterparts. In a precedent work we observed that respiratory pig DC and Macrophages were more similar to the human ones than to the mouse ones. In the present work, thanks to our animal model, we were able to collect the rare bronchoalveolar DC and compare them to their interstitial counterparts. We observed that DC presented very similar gene-expression patterns in the alveolar and interstitial compartments, validating the study of human bronchoalveolar DC as surrogate of their interstitium counterparts.
Medical subject headings
- Dendritic Cells
- Gene Expression
- Intestines
- Macrophages, Alveolar