LEAP: constructing gene co-expression networks for single-cell RNA-sequencing data using pseudotime ordering.
basic_science · Level V
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- Record sourced from PubMed, PMID 27993778.
- Also identified by DOI 10.1093/bioinformatics/btw729 and PMC identifier 5860270.
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Abstract
To construct gene co-expression networks based on single-cell RNA-Sequencing data, we present an algorithm called LEAP, which utilizes the estimated pseudotime of the cells to find gene co-expression that involves time delay. R package LEAP available on CRAN. jun.li@nd.edu. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Gene Expression Profiling
- Gene Regulatory Networks
- Sequence Analysis, RNA
- Single-Cell Analysis
- Software