Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.

Wang, Hui; Revia, Richard; Wang, Kui; Kant, Rajeev J; Mu, Qingxin; Gai, Zheng; Hong, Kunlun; Zhang, Miqin · Adv Mater · 2017

basic_science · Level V

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Abstract

A boron-doped graphene quantum dot (B-GQD) as a metal-free multimodal contrast agent (CA) for safe magnetic resonance imaging and fluorescence imaging is reported. In vivo T<sub>1</sub> -weighted magnetic resonance images show that B-GQDs induce significant contrast enhancement on the heart, liver, spleen, and kidney, and sustain for more than 1 h, about 10 times longer than Gd-based CAs currently used in clinic.