Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28026134.
- Also identified by DOI 10.1002/adhm.201601011.
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Abstract
d-type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L-type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.
Medical subject headings
- Anti-Infective Agents
- Escherichia coli
- Nanoparticles
- Peptide Synthases
- Staphylococcus aureus