Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae.
basic_science · Level V
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- Record sourced from PubMed, PMID 28031484.
- Also identified by DOI 10.1073/pnas.1619369114 and PMC identifier 5255579.
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Abstract
RNAs besides tRNA and rRNA contain chemical modifications, including the recently described 5' nicotinamide-adenine dinucleotide (NAD<sup>+</sup>) RNA in bacteria. Whether 5' NAD-RNA exists in eukaryotes remains unknown. We demonstrate that 5' NAD-RNA is found on subsets of nuclear and mitochondrial encoded mRNAs in Saccharomyces cerevisiae NAD-mRNA appears to be produced cotranscriptionally because NAD-RNA is also found on pre-mRNAs, and only on mitochondrial transcripts that are not 5' end processed. These results define an additional 5' RNA cap structure in eukaryotes and raise the possibility that this 5' NAD<sup>+</sup> cap could modulate RNA stability and translation on specific subclasses of mRNAs.
Medical subject headings
- RNA Caps
- RNA, Fungal
- Saccharomyces cerevisiae