Reversible RNA modifications in meiosis and pluripotency.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28032624.
- Also identified by DOI 10.1038/nmeth.4111.
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Abstract
Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.
Medical subject headings
- Epigenesis, Genetic
- Meiosis
- Pluripotent Stem Cells
- RNA