Training alignment parameters for arbitrary sequencers with LAST-TRAIN.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28039163.
- Also identified by DOI 10.1093/bioinformatics/btw742 and PMC identifier 5351549.
- Licence recorded as CC BY-NC.
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Abstract
LAST-TRAIN improves sequence alignment accuracy by inferring substitution and gap scores that fit the frequencies of substitutions, insertions, and deletions in a given dataset. We have applied it to mapping DNA reads from IonTorrent and PacBio RS, and we show that it reduces reference bias for Oxford Nanopore reads. the source code is freely available at http://last.cbrc.jp/. mhamada@waseda.jp or mcfrith@edu.k.u-tokyo.ac.jp. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genome, Human
- Polymorphism, Genetic
- Sequence Analysis, DNA
- Software