PBIT: Pipeline Builder for Identification of drug Targets for infectious diseases.
basic_science · Level V
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- Record sourced from PubMed, PMID 28039165.
- Also identified by DOI 10.1093/bioinformatics/btw760.
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Abstract
PBIT (Pipeline Builder for Identification of drug Targets) is an online webserver that has been developed for screening of microbial proteomes for critical features of human drug targets such as being non-homologous to human proteome as well as the human gut microbiota, essential for the pathogen's survival, participation in pathogen-specific pathways etc. The tool has been validated by analyzing 57 putative targets of Candida albicans documented in literature. PBIT integrates various in silico approaches known for drug target identification and will facilitate high-throughput prediction of drug targets for infectious diseases, including multi-pathogenic infections. PBIT is freely accessible at http://www.pbit.bicnirrh.res.in/ . thomass@nirrh.res.in. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Communicable Diseases
- Computer Simulation
- Drug Discovery
- Microbiota
- Proteome