Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28039355.
- Also identified by DOI 10.1093/infdis/jiw638 and PMC identifier 5854042.
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Abstract
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
Medical subject headings
- Antibodies, Viral
- Antibody-Dependent Enhancement
- Dengue Virus
- Zika Virus
- Zika Virus Infection