Role of innate and adaptive immunity in obesity-associated metabolic disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28045397.
- Also identified by DOI 10.1172/JCI88876 and PMC identifier 5199693.
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Abstract
Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR). Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process. Thus, M1 macrophages, IFN-γ-secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part through secretion of proinflammatory cytokines. Conversely, eosinophils, Th2 T cells, type 2 innate lymphoid cells, and possibly Foxp3+ Tregs protect against IR through local control of inflammation.
Medical subject headings
- Adaptive Immunity
- Adipose Tissue
- Immunity, Innate
- Insulin Resistance
- Obesity