Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo.

Zou, Yan; Wei, Yaohua; Wang, Guanglin; Meng, Fenghua; Gao, Mingyuan; Storm, Gert; Zhong, Zhiyuan · Adv Mater · 2017

basic_science · Level V

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Abstract

Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.

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