Ultrasensitive Phototriggered Local Anesthesia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28058845.
- Also identified by DOI 10.1021/acs.nanolett.6b03588 and PMC identifier 5469101.
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Abstract
An injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1-2 min of irradiation at ≤272 mW/cm<sup>2</sup> produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light.
Medical subject headings
- Anesthesia, Local
- Liposomes
- Nanotubes
- Nerve Block