Surveillance for Secure Differentiation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28061352.
- Also identified by DOI 10.1016/j.stem.2016.12.011.
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Abstract
The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.
Medical subject headings
- Cell Differentiation
- Signal Transduction