Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28061354.
- Also identified by DOI 10.1016/j.stem.2016.12.008.
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Abstract
Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.
Medical subject headings
- DNA (Cytosine-5-)-Methyltransferases
- Leukemia, Myeloid, Acute