CRYPTOCHROME mediates behavioral executive choice in response to UV light.
basic_science · Level V
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- Record sourced from PubMed, PMID 28062690.
- Also identified by DOI 10.1073/pnas.1607989114 and PMC identifier 5278478.
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Abstract
Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.
Medical subject headings
- Choice Behavior
- Cryptochromes