Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.
basic_science · Level V
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- Record sourced from PubMed, PMID 28062691.
- Also identified by DOI 10.1073/pnas.1608839114 and PMC identifier 5278460.
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Abstract
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA sequencing and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Δ778-786) generated by a focal deletion-driven alternative splicing mechanism as well as novel VAV1 gene fusions (VAV1-THAP4, VAV1-MYO1F, and VAV1-S100A7) in PTCL. Mechanistically these genetic lesions result in increased activation of VAV1 catalytic-dependent (MAPK, JNK) and non-catalytic-dependent (nuclear factor of activated T cells, NFAT) VAV1 effector pathways. These results support a driver oncogenic role for VAV1 signaling in the pathogenesis of PTCL.
Medical subject headings
- Guanine
- Guanine Nucleotide Exchange Factors
- Lymphoma, T-Cell, Peripheral
- Mutation
- Proto-Oncogene Proteins c-vav
- Translocation, Genetic