Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28065337.
- Also identified by DOI 10.1016/j.jaip.2016.09.028 and PMC identifier 5930011.
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Abstract
Recognition of non-SCID and secondary causes of T cell lymphopenia detected by TREC newborn screening is important in directing subsequent care and identifying those who would not benefit from more invasive interventions. Here, we report two infants with low TRECs and severe, but self-resolving, T cell lymphopenia identified by SCID NBS that were caused by <i>in utero</i> exposure to purine antimetabolites.
Medical subject headings
- Aza Compounds
- Immunosuppressive Agents
- Lymphopenia
- Mercaptopurine
- Prenatal Exposure Delayed Effects
- Purines
- Receptors, Antigen, T-Cell
- Severe Combined Immunodeficiency
- T-Lymphocytes